The Clinical Studies Have Spoken:
Mankai Gives You More!

Since its introduction to western culture, Mankai's amazing traits have intrigued the global ‎science community. ‎

A list of groundbreaking clinical studies conducted by leading universities and research ‎institutions, which were published in journals dedicated to nutrition and medicine, ‎analyzed Mankai's advantages and positive influence on human health. ‎

One of these studies – a large-scale international collaboration between Ben Gurion and ‎Harvard Universities – examined the impact of a Mankai-enhanced Green-Mediterranean ‎diet on bodily functions and health. ‎

The results, including the results of a large clinical trial that analyzed 300 participants over 18 ‎months, and compared a classic Mediterranean diet to a Green-Mediterranean diet rich in ‎polyphenols-Supplied by Mankai, amazed the global science community. In fact, the ‎staggering results led to a long list of studies that attempted to decipher the power of this ‎tiny SuperGreen. ‎

A source of highly absorbed iron ‎

Published results of an 18-month clinical study revealed that participants following the ‎Green-Mediterranean Diet group‏ ‏‎— which included reduced consumption of animal-based ‎foods and a daily Mankai shake — maintained significantly higher and more stable iron ‎status indicators (hemoglobin, plasma iron and transferrin) compare to the other study ‎groups. Complementary findings from a rat model demonstrated that Mankai ‎supplementation also reversed anemia.‎

The report was published in‎ THE JOURNAL OF NUTRITION.

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Vitamin B12, both bioactive and bioavailable

Studies have clearly shown that Mankai, as opposed to other plants, is a natural source of ‎vitamin B12 in all three of its active forms. Additional studies demonstrated that Mankai’s ‎B12 is highly bio available — with daily consumption leading to increased blood B12 levels, ‎even in individuals who consume less animal-based foods. ‎

Moreover, a focused study using an artificial intestine model found that Mankai ‎consumption significantly boosts the abundance of gut microbiota involved in vitamin B12 ‎absorption, likely contributing to its high bioavailability.‎

The study was published in‎ NUTRIENTS.

A high-quality alternative to animal-based protein

Over 40% of Mankai's dry matter is made up of complete protein, which includes all the ‎essential amino acids, in a ratio aligned with FAO recommendations — similar to the amino ‎acids profile of egg protein. A comparative study revealed that Mankai amino acid ‎digestibility is high, comparable to that of white cheese. ‎

According to this report, Mankai is a rich source of high-quality complete protein that can ‎replace animal-based protein. ‎

The study was published in‎ Clinical Nutrition.

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Balancing sugar and improving insulin activity

A dedicated clinical study examined the impact of incorporated Mankai into a daily diet on ‎blood sugar levels. The results demonstrated that daily Mankai consumption helps ‎maintain balanced blood glucose levels throughout the day, while enhance insulin ‎sensitivity. Participants also reported on increased feeling of satiation after consuming a ‎Mankai shake.‎

The study was published in‎ DIABETES CARE

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Reducing blood sugar levels in patients with type 2 diabetes

The benefits extended beyond healthy individuals.
A clinical study involving type 2 ‎diabetes patients conducted by Sheba Medical Center and Ben Gurion University, found ‎that consuming Mankai after a meal led to a significant reduction in post-meal blood sugar ‎levels in those T2D patients (approx. 20%).‎

The study was published in‎ Diabetes ,Obesity and Metabolism

A significant deceleration in age-related brain atrophy

A clinical study, along with supporting research, examined the effect of a Mankai-rich ‎Green-Mediterranean diet — which included reduced consumption of animal-based foods ‎and a daily Mankai shake — on age-related brain atrophy within subjects aged 50 on ‎average. MRI analysis over the 18-month study period revealed that the Mankai ‎polyphenol-rich diet significantly slowed age-related brain atrophy and was associated with ‎reversal of brain aging by approximately 3 years. ‎

The study results were published in two articles:‎

‎The American Journal of Clinical Nutrition.‎

‎The American Journal of Clinical Nutrition.‎

Improvement of cardiovascular system and proximal aortic stiffness

A large clinical study, analyzing 300 participants over 6 months, compared a western diet, a ‎classic Mediterranean diet and a Green-Mediterranean diet (which included reduced ‎consumption of animal-based foods and a daily polyphenol-rich Mankai shake). The results ‎revealed that the Mankai-rich Green - Mediterranean diet led to significant improvements ‎in various cardiometabolic parameters, including LDL, HDL/LDL ratio, blood pressure and ‎more.‎

This study was the first to exhibit the significant impact of a Mankai-rich Green —‎Mediterranean diet on aortic stiffness, showing that including Mankai in the daily diet ‎doubled the reduction in proximal aortic stiffness. This improvement was correlated with ‎an improved fasting glucose level, contributing to enhanced cardiovascular health.‎

The study was published in‎ HEART
And also in a leading cardiology journal‎ JACC (Journal of the American College of Cardiology).

Reduction of intra-tissue fat in liver

An 18-month clinical study demonstrated that a Green-Mediterranean diet ‎supplemented with polyphenol-rich Mankai led to the largest reduction in liver fat – ‎almost doubled - compared to a classic Mediterranean diet. This suggests a potential ‎benefit in lowering the risk of non-alcoholic fatty liver disease.‎

The study was published in‎ GUT

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A unique and positive effect on gut microbiota activity

A dedicated clinical study examined the impact of diet on gut microbiota profile. The results ‎surprisingly revealed that including polyphenol-rich Mankai in a Green —Mediterranean ‎diet had a beneficial effect on the gut microbiome profile, helping to preserve weight loss ‎achieved after six months and maintaining balanced blood glucose levels. ‎

Intrigued by the clinical trial results, a follow-up study using an artificial intestine system ‎examined Mankai's direct impact on the gut microbiota. The results revealed that Mankai ‎selectively influence microbial composition by breaking down polyphenols into smaller ‎phenolic acids beneficial for human health. ‎

The study was published in‎ GUSTROANTOLOGY
And also in the‎ Journal of Functional Foods.

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